Breast cancer metastasis is a complicated process driven by multiple genes and follows multiple steps
Most metastatic cancers are incurable. But most also are treatable. Chemotherapy drugs, radiation and other treatments can extend a patient’s life. The treatment for metastasis of malignant tumor is a tough problem to the clinical oncology, because tumor metastasis is the causa mortis of majority of cancer patients. Recognation of metastasis /invasion related gene will has a great significance in preventing and curing breast carcinomatous metastasis. Breast cancer metastasis is a complicated process driven by multiple genes and follows multiple steps. The regulation of metastasis-associated genes is the molecular basis for metastasis.
In 2005 the Memorial Sloan-Kettering Cancer Center, The research team has found a series of genes, Including: EREG, MMP1, MMP2 and COX2. These four genes can cause cancer metastasis. Vessel was kidnapped by four genes, and then supports the growth of primary tumors. Help cancer cells move to the lungs. Four genes help cancer cells squeeze through the capillary walls, and then Settle down there. So researchers hope that their new research will be able to enhance the efficacy of the cocktail. Several drugs and cocktail therapy can prevent breast cancer metastasis.
Cocktail therapy refers to the original “highly active antiretroviral therapy, ” by the Chinese-American scientist David Ho in 1996. Existing cocktail can kill the body throughout the cycle of the virus, but not touch these viruses Act hangar latent virus. Breast cancer metastasis is the main symptom of advanced cancer, Depression affects 25% of patients with advanced cancer. the stage at which the disease has begun to spread from its original tumour. Massague opposed to this traditional view from the Memorial Sloan-Kettering Cancer Center. Primary cancer cells have the ability to transfer. Specific genes can promote tumor growth while helping to metastasis. Whether These four genes help other cancer cells metastasis has not been determined.Another potential contribution this study makes is the possibility that these same genes are involved in fuelling metastasis of other cancers, or at least that similar rules are involved.
Metastasis of cancer cells to sites away from the main tumor can cause pain and other symptoms and greatly increases the likelihood a patient will die of the disease. Breast cancer metastasis causes nearly 90% of the lethality among breast cancer patients. Surgery can reduced the number of patients with metastasis and compounded, there will be a potential 30%
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