Medication Information: Cetrotide
Cetrotide is a gonadotropin releasing hormone antagonist which comes in simple and flexible form of administration. Normally, it is delivered via the subcutaneous route and comes in preparations containing 3mg or 0.25mg of the active ingredient. Usually, this medication may be given on the 5th and seventh day of the menstrual cycle.
Your body’s response to hormones will affect the maturation of egg cells and Cetrotide comes in to help with that. This medication will delay the LH surge in women that usually the main reason of infertility.
This LH surge takes place when there are changes in luteinizing and gonadotropin releasing hormones. If there are increase levels of gonadotropin releasing hormone in your body your pituitary gland will stimulate an increase level of LH as a response. LH is in charge of releasing eggs even if they reach full growth or not. If there is an increase in LH levels before full development of egg cells, no ovulation will happen.
Premature release of unripe eggs will be avoided with Cetrotide. Because of this, pregnancy may happen.
It is necessary to report to your fertility physician and review the risk and advantages of this drug. There have been reports of side effects and adverse effects of this drug. Such side effects are soreness, reddening and swelling at the injection site, nausea and vomiting and head aches. There have been no scientific studies conducted on its drug-drug interaction. This drug is contraindicated to females with known hypersensitivity to cetrotide and its components, allergic reactions to GnRH drugs, pregnancy, lactation and patients who have renal and heart problems.
During first drug therapy, patients may have an allergy. Some of the allergic reactions include skin rash, persistent cough and reduced blood pressure. Observe caution in using the medication on patients who are hypersensitive to any food or drugs. For the treatment to be a success, the couple’s comprehension of the whole procedure is vital. The evaluation of the effectiveness and safety of the therapy must be done by the doctor and he should also make sure that all needed procedures are being followed.
Studies have been conducted and 316 newborns from a Cetrotide mother, develop anencephaly and died immediately and 4 pregnancies were terminated. Some of the minor birth abnormalities include the presence of benign skin injury and melanocytes, imperforated hymen and babies who are delivered as cross-eyed. There have no known information concerning the overdosing of this medication.
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