Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is a disorder which affects the normal functioning of the body hormones, resulting in the failure of the insulin to control the amount of glucose in the body, which results in hyperandrogenism, polycystic ovaries and insulin resistance.
Polycystic ovary disorder is an analysis undertaken in five to ten percent of women between the age of late teens and the menopause. Patients with PCOS disorder may suffer from amenorrhoea or oligomenorrhoea, infertility or anovulation, acne or hirsutism conditions (Birdshall p 38).
Women suffering from polycystic ovarian syndrome are at a higher risk of getting ischaemic heart disorder and myocardial infarction than other woman, and at the age of forty years about forty percent will be suffering from type 2 diabetes disorders or glucose impaired tolerance.
The standard therapy for treatment of symptoms of hyperandrogenism is by suppressing the production process of ovarian testosterone with an oral progestogen /oestrogen contraceptive, frequently with the inclusion of the antiandrogenical progestogen cyproterone contraceptive acetate. Anovulation and Infertility are frequently treated with laparoscopically or gonadotropins and clomiphene citrate, Appling physical therapies to the ovaries, such as diathermy or laser Open wedges resections of ovaries is hardly ever used for the reason that the risk of disruptive infertility from adhesions (Hull p 67).
On the other hand, Insulin Resistance is a condition where by, for a given volume of insulin, there is less than usual decrease of sugar. The pancreas beta cells
Primarily, produces excess insulin to compensate for this resistance. If, glucose amounts are control within usual ranges, an individual simply suffer from Insulin Resistance with high insulin amounts. However, if an individual glucose amounts are fairly high, an individual suffers from Impaired Glucose Tolerance. In addition if sugar levels are extremely high an individual suffers from type 2 diabetes. With time, an individual having Insulin resistance disorder has disposition to progress from very high insulin amounts with usual glucose to unusually very high levels of glucose, which is impaired glucose resistance or type two diabetes disorder.
At a time When beta cells off the pancreas can not be in a position of producing the larger amounts of insulin required in Insulin Resistance to regulate levels of glucose, insulin levels reduces in volumes giving way for unusually high levels of glucose to develops, leading primary in impaired glucose resistance, and eventually if not rectified the condition develops in to type two diabetes.
How is Insulin Resistance related to PCOS?
Due to very high levels of insulin as a result of Insulin Resistance, the ovary is stimulated to produce very high levels of androgens. Furthermore very high levels of insulin reduces levels of SHBG,leading to an increase in the androgens potency.
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