Pharmaceutical flexible packaging composite film technology of heat sealing bag – pharmaceutical flexible packaging, composite membrane – the pharmaceutical industries
Recent years, with the pharmaceutical industry as well as kits rapid development, particularly proprietary, granules, powders and other pharmaceutical market continues to expand, Flexible Packaging Bags because of its good barrier, in the cartridge occupies an increasing area ratio. As the number of PTP barrier blister packaging requirements, making use of certain drugs in blister packs in the packaging after the need to add a layer of composite membrane outside the flexible bag, in order to enhance the protection of the drugs to prevent moisture and light external factors on the efficacy of pharmaceutical packaging damage. This paper bag making process on some of the key process parameters and the actual production process, some of the problems that often appear simple exposition and research.
Present, sealing joint is used in composite packaging materials, the most common and most practical way of a bag. It is the use of external conditions (such as electric heating, high frequency voltage and ultrasonic, etc.) to make plastic film heat sealed into a viscous flow state area, and with a certain pressure on the two membrane fusion as a whole, after cooling to maintain strength. There are many ways sealing together, such as fuse sealing, ultrasonic sealing, high frequency sealing, thermal air seal, rod sealing, etc. together. Under Pharmaceutical Packaging Characteristics and requirements of the pharmaceutical flexible packaging bags are mostly combined with bar-type seal, it is in the bag industry, the most common form of joint sealing methods. This seal is mainly through the heating temperature, sealing time, heating rods and the three silica gel plates coordination between the pressure and eventually reach a satisfactory sealing effect. Generally speaking, a good sealing effect depends on whether it has good heat seal strength and intact appearance.
1, the three elements of sealing bag
Practice, we said the heat sealing temperature, seal time, pressure seal bag heat sealing the three elements.
1. Sealing temperature Is the role of sealing temperature heating film bonded to an ideal state of viscous flow.
Since no definite melting point of polymer, is a melting temperature range, ie between the solid phase and liquid phase has a temperature region, when heated to the temperature region, the membrane into the molten state. Polymer viscous flow temperature and decomposition temperature are the heat sealing of the lower and upper limit, viscous flow temperature and decomposition temperature is a measure of the size difference between the difficulty of sealing an important factor.
Sealing temperature properties of the materials under seal, film thickness, sealing the frequency and hot press sealing area the size of the set. Hot pressure increase in the number one position, the temperature can be appropriately reduced, sealing large area, the temperature can be slightly higher.
In the sealing compound bag processing, heat sealing temperature on the seal strength of the most direct, the melting temperature of various materials will directly determine the minimum sealing temperature bag. In the actual production process, the sealing temperature heat sealing pressure bag machine speed and the thickness of the substrate complex factors, and thus the actual sealing temperature is often higher than the melting temperature of sealing materials. If the sealing material sealing temperature lower than the softening point, then whatever the pressure to increase or extend the sealing time, sealing layer can not really seal. In general, as the sealing temperature increases, the heat seal strength will increase, but to a certain temperature, the intensity will not increase (see Figure 1 seal strength with temperature). If the sealing temperature is too high, easy to damage the sealing materials, welding, melt extrusion lead to "undercut" phenomenon and greatly reduce the sealing of the seal strength and impact resistance of composite bag.
2. Sealing time Film sealing time is the time to stay in the hot sword, it is also affecting the appearance of heat seal strength and a key factor. The same heat sealing temperature and pressure, heat sealing a long time, the heat sealing layer fusion more fully, combined with more solid. But the sealing time is too long, likely to cause wrinkling seal weld deformation, impact and appearance of flatness; while sealing time is too long, will cause decomposition of molecules, so that sealing performance deterioration of the interface seal.
General sealing time mainly by the speed of decision making machine. Old bag making machine, adjust bag sealing time only by changing the machine's speed, to extend the sealing time, would have to sacrifice productivity. In recent years, bag making machine manufacturers at home and abroad using a separate frequency control of motor technology sealing knife down and feed, so making machine can not change the speed bag sealing under independent regulation time or in the control of sealing time independent regulator under the same bag speed bag making machine greatly facilitated the operation and quality control, improved bag making machine production efficiency.
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