Four types of drugs cause damage to the kidneys need to be cautious to take – drugs – pharmaceutical industries
Some drugs frequently encountered after oliguria, facial swelling, to the hospital examination revealed kidney problems, by asking know that this is caused by taking certain drugs. So, what caused the kidney drugs easily damage?
1, aminoglycosides, tetracycline, Cephalosporin Cephalothin: aminoglycoside should not be long-term continuous use, on the basis of renal function in patients with poor kidney poisoning is more likely to reach the threshold. Renal toxicity of these drugs on the level of the order, gentamicin> amikacin> streptomycin.
Gentamicin nephrotoxicity than neomycin. Renal toxicity manifested as blood urea nitrogen, creatinine increase, in severe cases of acute renal failure. Gentamicin and amphotericin Pioneer , Vanguard ADM , lincomycin, furosemide and other drugs with enhanced renal toxicity.
Amikacin and streptomycin in renal toxicity symptoms were manifested as proteinuria, urinary casts, hematuria, abnormal urine, etc.. Followed by peptide Antibiotic : Polymyxin B has high toxicity to the kidney may cause renal tubular degeneration, necrosis, particularly in elderly patients. Lesion in the proximal tubule, clinical manifestations were proteinuria, hematuria, urinary tube and other urinary abnormalities, azotemia may also occur.
Penicillin class of antibiotics has long been considered to be minimal toxic drug, however, a new penicillin I, ampicillin, a broad-spectrum semisynthetic penicillin Cerbenicillin, which have caused kidney damage were reported.
Mainly penicillins, renal vascular inflammation, renal inflammation, acute renal failure and acute interstitial nephritis. Vanguard ADM principal is kidney damage and allergic reactions directly. Vanguard ADM with furosemide or aminoglycosides may increase with time on kidney toxicity. Therefore, to remind you to refrain from indiscriminate use of antibiotics.
2, anti-inflammatory drugs: long-term large doses of chronic renal toxicity appear. Aspirin and paracetamol overdose can cause renal necrosis, two drugs is greater than the toxicity alone. Abuse of analgesics containing phenacetin patients, interstitial nephritis and renal papillary necrosis occur.
Otherwise reported in the literature, indomethacin, Phenylbutazone, Ibuprofen, phenoxyacetic acid and calcium are also duality prostaglandin inhibitors can cause renal failure. The joint application of analgesics, aspirin is a common ingredient. Analgesic nephropathy induced in etiology, the toxicity of aspirin, there are still controversial, however, animal experiments than aspirin phenacetin more prone to kidney papillary necrosis. Some personnel to monitor the cells in urine and found that the toxicity of aspirin on the kidneys than phenacetin are strong.
3, sulfa: renal damage, including vascular inflammation, urinary tract obstruction, renal tubular necrosis, interstitial nephritis. Light may have hematuria, proteinuria, and might appear anuria, uremia, renal failure. Urinary tract symptoms in 62% of patients with urine pH values less than 5? 5, some solubility in acidic urine, low sulfa drug and acetyl compounds are easy to precipitate crystals.
4, cardiovascular system drugs: treatment of heart failure such as digoxin and the blood pressure of nifedipine, in the application process should pay attention to the dose of drug use. Some drugs used to treat epilepsy can cause a typical syndrome, more than half of children using the drug appeared hematuria, proteinuria and other renal injury, so the process should also be used to observe the urine.
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