Starch, starch and dry starch in the preparation of the application – starch – t
In general, starch is insoluble in water, dispersed in water, 60 to 70 degrees Celsius swelling characteristics. Often used as diluent, binder, disintegrating agent, and can be used to prepare dextrin and starch.
1 used as a diluent (Diluents): diluent (otherwise known as fillers, Fil1ers) primary role is to fill the weight or volume of the tablet to facilitate molding and sub-dose preparations to facilitate the pressure plate; commonly used fillers are starch, sugar, cellulose and inorganic salts and so on.
To starch as a diluent, the more common corn starch, it is the nature of the very stable, and most of the drugs does not work, the price is relatively cheap, little moisture absorption, good color and appearance, in the actual production, often and compressibility, good sugar, dextrin mix because of starch may be less pressure, if used alone, will press out the pills too loose.
2 is used as adhesive (Adhesives): certain drugs powder itself does not have sticky or viscous small, need to add starch and other viscous material, bonded together to make it this time by adding the viscous substance called adhesives.
Starch syrup (commonly known as starch paste) is the most commonly used adhesive tablet, commonly used in 8% and 15% of the concentration, and to 10% of the most commonly used starch; if compressible materials is poor, can be further increased due the concentration of starch to 20%, the opposite may also be appropriate to reduce the concentration of starch, such as aluminum hydroxide tablets or 5% starch as binder. The making of starch mainly pulp and red pulp cooked two ways, are able to use the starch pasting properties. The so-called pasting (Gelatinization) is heated starch paste to form a uniform phenomenon (corn starch is completely gelatinized temperature 77 ). Gelatinization, the starch viscosity increases sharply, which can be used as a tablet binder. Specifically, the red pulp is the residue was suspended in a small amount of starch (1 to 1.5 times) in water, and then into the concentration required a certain amount of boiling water, stirring constantly paste made; cooked starch slurry is the amount of residue was suspended in all water containers in the laminated heat and keep stirring (should not use direct heat, in order to avoid coking), until the paste. Cheap and easy to get and because the starch adhesion is good, so who can use starch tablet granulation and to meet the requirements, the majority of this starch binder used.
3 used as a disintegrating agent (Disintegrants): disintegrating tablets in the gastrointestinal fluid to enable rapid crack broken into small particles of matter, in addition to slow (controlled) release tablets and the tablets of some special purpose other than in general should join the disintegrating tablet. Because of their strong water absorption expansion, to the collapse of the combination tablet, giving tablets whole flakes from a crack broken into many small particles to achieve tablet disintegration, so very favorable tablet Main drug dissolution and absorption.
Dry starch is one of the most classic of the disintegrating agent, water content below 8%, water absorption and there is some strong expansion, is more suitable for water insoluble or slightly soluble drugs, tablets, but on the Soluble disintegration of the drug less, because the solution with water soluble drug produced a concentration difference, to make tablets out of the water level is not easy penetration through the solution to the tablets inside, impede water swelling starch inside tablets. In production, generally applied law, in addition, or "external addition" to achieve the desired disintegration effect.
Starch as a tablet disintegrating agents of disadvantages: First, starch can pressure is bad, the dosage for a long time, can affect the hardness of tablets. Secondly, the mobility of starch is not good, plus too much starch will affect the particle mobility. Preparation of dextrin
4: dextrin (C6H10O5) x, from the starch by acid or heat treatment or the role of a-amylase formed product of the incomplete hydrolysis may be used to prepare a variety of liquid or solid adhesive.
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