A rare genetic map of the inflection point occurs Clinical Research – gene mappi
1 22 21, the Chinese, British and American scientists, "International Cooperation Group" in Shenzhen, London and Washington also announced that the international "thousands of genome project" was officially launched.
This international cooperation project sponsors and major stakeholders, including the UK's Sanger Institute, Beijing Genomics Institute in Shenzhen, China and the U.S. subsidiary of the U.S. National Institutes of Health Human Genome Research Institute.
Genomics Institute, Shenzhen, Vice President Dr. Wang Jun noted that the plan is a continuation of the Human Genome Project and development, will be selected from the determination of at least 1,000 people around the world class individual genome DNA sequence, rendering most detailed to date , the most valuable medical applications of genetic polymorphism of the human genome map.
New map of the new value
Scientific research shows that any two people at the genetic level, 99% is the same, only a small part of the genome sequence varies. Experts point out that understanding these differences is important, it helps us to understand the susceptibility to disease among people, drugs and environmental factors on the response of different.
Current human genetic variation data, such as the human genome haplotype map has been proven to be valuable for human genetic research. The use of haplotype maps and related data, scientists have discovered more than 100 common diseases associated with human genomic regions. These common diseases including diabetes, coronary heart disease, prostate and breast cancer, arthritis, colitis, and age-related macular degeneration, etc..
However, the existing map detail is not enough, researchers often need expensive and time-consuming DNA sequencing to further pinpoint the causative genes and their variations. Beijing Genomics Institute
spokesman pointed out that "thousands Genome Project" will be in different countries through multi-disciplinary research team of experts to work together, ultimately drawing a biomedical associated with human genetic polymorphism new map. The new map is a cover almost the whole of mankind genome map of genetic variation, including all frequencies in the population is not less than 1% of the variance, and the frequency of those less than 0.5% of the variation in the gene will be within the identified to. As the new map of the resolution will be greatly enhanced, allowing researchers more quickly lock and disease-related gene variants point to be able to use genetic information to develop common diseases faster diagnosis, treatment and prevention of new strategies.
To this end, the project will be more than 1000 individuals determined genome sequence. Individuals have been sequenced are anonymous, methods will not release their names, not to disclose their medical information.
The U.S. Human Genome Research Institute Francis? Dr Collins said: "This new program will we find the sensitivity of disease-related mutation in the genomic DNA level increased 5-fold, while genes in the region will increase the sensitivity of more than 10 times. We existing database has been covered in the crowd of more than 10% frequency of polymorphisms. With the new high-throughput sequencing technology and a newly developed method, we hope to provide biomedical researchers covering the entire genomes frequency of 1% of the variance. This will completely change our disease research. "
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